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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha : |
15/04/2021 |
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Actualizado : |
15/04/2021 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Autor : |
COSTA, D.; LÉVESQUE, S.; KUMAR, N.; FRESIA, P.; FERRÉS, I.; LAWLEY, T. D.; IRAOLA, G. |
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Afiliación : |
DANIELA COSTA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Sección Genética Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay; SIMON LÉVESQUE, Laboratoire de Santé Publique du Québec, Quebec City, Canada; NITIN KUMAR, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; PABLO FRESIA, Unidad Mixta UMPI, Institut Pasteur Montevideo + INIA, Montevideo, Uruguay; IGNACIO FERRÉS, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; TREVOR D. LAWLEY, Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; GREGORIO IRAOLA, Microbial Genomics Laboratory, Institut Pasteur Montevideo, Montevideo, Uruguay; Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK; Center for Integrative Biology, Universidad Mayor, Santiago de Chile, Chile. |
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Título : |
Pangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts. |
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Fecha de publicación : |
2021 |
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Fuente / Imprenta : |
Scientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9 |
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ISSN : |
2045-2322 |
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DOI : |
10.1038/s41598-021-82993-9 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021. |
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Contenido : |
ABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens.
© 2021, The Author(s). MenosABSTRACT.
Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the under... Presentar Todo |
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Palabras claves : |
Computational biology and bioinformatics; Evolution; Microbiology. |
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Asunto categoría : |
A50 Investigación agraria |
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URL : |
https://www.nature.com/articles/s41598-021-82993-9.pdf
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Marc : |
LEADER 02962naa a2200265 a 4500
001 1061986
005 2021-04-15
008 2021 bl uuuu u00u1 u #d
022 $a2045-2322
024 7 $a10.1038/s41598-021-82993-9$2DOI
100 1 $aCOSTA, D.
245 $aPangenome analysis reveals genetic isolation in Campylobacter hyointestinalis subspecies adapted to different mammalian hosts.$h[electronic resource]
260 $c2021
500 $aArticle history: Received 12 February 2018; Accepted 24 January 2021; Published 09 February 2021.
520 $aABSTRACT. Campylobacter hyointestinalis is an emerging pathogen currently divided in two subspecies: C. hyointestinalis subsp. lawsonii which is predominantly recovered from pigs, and C. hyointestinalis subsp. hyointestinalis which can be found in a much wider range of mammalian hosts. Despite C. hyointestinalis being reported as an emerging pathogen, its evolutionary and host-associated diversification patterns are still vastly unexplored. For this reason, we generated whole-genome sequences of 13 C. hyointestinalis subsp. hyointestinalis strains and performed a comprehensive comparative analysis including publicly available C. hyointestinalis subsp. hyointestinalis and C. hyointestinalis subsp. lawsonii genomes, to gain insight into the genomic variation of these differentially-adapted subspecies. Both subspecies are distinct phylogenetic lineages which present an apparent barrier to homologous recombination, suggesting genetic isolation. This is further supported by accessory gene patterns that recapitulate the core genome phylogeny. Additionally, C. hyointestinalis subsp. hyointestinalis presents a bigger and more diverse accessory genome, which probably reflects its capacity to colonize different mammalian hosts unlike C. hyointestinalis subsp. lawsonii that is presumably host-restricted. This greater plasticity in the accessory genome of C. hyointestinalis subsp. hyointestinalis correlates to a higher incidence of genome-wide recombination events, that may be the underlying mechanism driving its diversification. Concordantly, both subspecies present distinct patterns of gene families involved in genome plasticity and DNA repair like CRISPR-associated proteins and restriction-modification systems. Together, our results provide an overview of the genetic mechanisms shaping the genomes of C. hyointestinalis subspecies, contributing to understand the biology of Campylobacter species that are increasingly recognized as emerging pathogens. © 2021, The Author(s).
653 $aComputational biology and bioinformatics
653 $aEvolution
653 $aMicrobiology
700 1 $aLÉVESQUE, S.
700 1 $aKUMAR, N.
700 1 $aFRESIA, P.
700 1 $aFERRÉS, I.
700 1 $aLAWLEY, T. D.
700 1 $aIRAOLA, G.
773 $tScientific Reports, 2021, Volume 11, Issue 1, Article number 3431. OPEN ACCESS. Doi: https://doi.org/10.1038/s41598-021-82993-9
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Registro original : |
INIA Las Brujas (LB) |
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| Registros recuperados : 11 | |
| 1. |  | ARCIA, P.; LÓPEZ, M.; BILLIRIS, A.; TRESSO, G.; SUBURÚ, G.; LUZARDO, C.; FIGUEREDO, V.; SANGUINETTI, M.N.; TERRA, J.A.; PÉREZ DE VIDA, F.; GONNET, D.; URAGA, R. Consolidando el trabajo en red. Arroz (ACA), 2020, v.20, no. 101, p.58-60. Proyecto financiado por ANNI "Red tecnológica del arroz: articulando producción, calidad y mercados y potenciando la sinergia de la cadena agroindustrial".| Tipo: Artículos en Revistas Agropecuarias |
| Biblioteca(s): INIA Treinta y Tres. |
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| 2. | | RUSSO, M.; ELICHALT, M.; VÁZQUEZ, D.; SUBURÚ, G.; SUBURÚ, G.; GILARDI, V.; ALMANDOS, V.; TIHISTA, H.; GODIÑO, M. Composición nutricional de productos elaborados en base a trigo en Uruguay. [Poster]. In: German, S.; Quincke, M.; Vázquez, D.; Castro, M.; Pereyra, S.; Silva, P.; García, A. (Eds.). Seminario Internacional "1914-2014: Un siglo de mejoramiento de trigo en La Estanzuela". Montevideo (UY): INIA, 2018. p. 259. (INIA Serie Técnica; 241).| Biblioteca(s): INIA La Estanzuela. |
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| 3. | | ELICHALT, M.; RUSSO, M.; VÁZQUEZ, D.; SUBURÚ, G.; TIHISTA, H.; GODIÑO, M. Lípidos, sodio y fibra dietética en harina de trigo y pan artesanal en Uruguay: aporte nutricional según recomendaciones para distintos grupos de población. [Lipids, sodium and dietary fiber in wheat flour and artisan bread in Uruguay: nutritional intake according to the recommendations for different population groups.] Revista Chilena de Nutrición, 44(1), p. 71-78., 2017. Este trabajo fue recibido el 25 de Mayo de 2016 y aceptado para ser publicado el 16 de Diciembre de 2016.| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : Internacional - -- |
| Biblioteca(s): INIA Las Brujas. |
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| 4. | | ELICHALT, M.; RUSSO, M.; VÁZQUEZ, D.; SUBURÚ, G.; TIHISTA, H.; GODIÑO, M. Lípidos, sodio y fibra en panes artesanales en el Uruguay : implicancias en la nutrición. In: CONGRESO LATINOAMERICANO DE NUTRICIONISTAS Y DIETISTAS (16., Montevideo,2015); CONGRESO IBEROAMERICANO DE NUTRICIÓN (6., Montevideo.2015). Poster.| Biblioteca(s): INIA La Estanzuela. |
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| 5. | | RUSSO, M.; ELICHALT, M.; VÁZQUEZ, D.; SUBURÚ, G.; GIOSCIA, G.; GILARDI, V.; ALMANDOS, V.; TIHISTA, H.; GODIÑO, M. Composición nutricional de productos elaborados en base a trigo en Uruguay. In: SEMINARIO INTERNACIONAL DE TRIGO, 2014, La Estanzuela, Colonia, UY. GERMÁN, S., et al. (Org.). 1914-2014, un siglo de mejoramiento de trigo en La Estanzuela: un valioso legado para el futuro: posters; resúmenes. La Estanzuela, Colonia, UY: INIA, 2014. p. 75.| Biblioteca(s): INIA La Estanzuela. |
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| 6. | | RUSSO, M.; ELICHALI, M.; VÁZQUEZ, D.; SUBURÚ, G.; TIHISTA, H.; GODIÑO, M. Fortification of wheat flour with folic acid and iron in Uruguay; implications for nutrition. [Fortificación de harina de trigo con ácido fólico y hierro en Uruguay; implicancias en la nutrición]. Revista Chilena de Nutrición, 2014, v.41, no.4, p. 399-403. OPEN ACCESS. Este trabajo fue recibido el 19 de Marzo de 2014 y aceptado para ser publicado el 16 de septiembre de 2014| Tipo: Artículos en Revistas Indexadas Internacionales | Circulación / Nivel : B - 1 |
| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas. |
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| 7. | | BOGLIACCINI, A.; AGUIAR, L.; FIORENTINO, G.; FRANCHI, S.; ROVETTA, N.; OTONELLI, H.; VÁZQUEZ, D.; TIHISTA, H.; SUBURÚ, G.; CADENAZZI, M.; CEA, J.; MORIYAMA, C.; GODIÑO, M. Caracterización anual de calidad de la zafra de trigo. In: MESA NACIONAL DE TRIGO. Informe de calidad e inocuidad de trigo Uruguayo: zafra 2013-2014. Montevideo, UY: MGAP, FAGRO, CIPU,INIA, LATU, 2013.| Biblioteca(s): INIA La Estanzuela. |
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| 8. | | ERNST, O.; ESCUDERO, J.; VÁZQUEZ, D.; CADENAZZI, M.; CASTRO, M.; GONZÁLEZ, N.; LARRAMENDI, S.; BENTANCUR, O.; SUBURU, G.; GODIÑO, M. Caracterización de la calidad industrial de variedades de trigo en Uruguay Montevideo (UY): INIA, 2012. 40 p. (Serie FPTA-INIA; 37) Proyecto FPTA 231: Caracterización de la calidad industrial de variedades de trigo sembradas para fabricación de harinas en Uruguay. Período de Ejecución: Nov. 2006-Abr. 2009| Biblioteca(s): INIA La Estanzuela; INIA Las Brujas; INIA Tacuarembó. |
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| 9. | | ERNST, O.; NIN, M.; CADENAZZI, M.; BENTANCUR, O.; GODIÑO, M.; SUBURU, G.; VÁZQUEZ, D. Manejo para rendimiento y calidad industrial de trigo : resultado final del relevamiento de chacras por variedades, de tres años sucesivos. ln: JORNADA DE RENDIMIENTO Y CALIDAD DE TRIGO, 4., 2002. Mercedes, Soriano, Uruguay [s.l.]: [s.n.], 2002. p. 1-23. Mesa de Nacional de Trigo, Uruguay.| Tipo: Trabajos en Congresos/Conferencias |
| Biblioteca(s): INIA La Estanzuela. |
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| 10. | | Ernst, O.; Bentancur, O.; Delucchi, I.; Suburu, G.; Godiño, M. Resultados en rendimiento y calidad : relevamiento de trigo zafra 1999/2000 ln: Jornada de rendimiento y calidad de trigo, 2., [2000], Mercedes, Uruguay [s.l.]: INIA, 2000. p. 1-19 Mesa Nacional de Trigo, Uruguay| Biblioteca(s): INIA La Estanzuela. |
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| 11. | | JORNADA DE RENDIMIENTO Y CALIDAD DE TRIGO, 3., 2001, MERCEDES, URUGUAY -; ERNST, O.; NIN, M.; CADENAZZI, M.; BENTANCUR, O.; CARAMESO, L.; SUBURU, G.; VÁZQUEZ, D.; DELUCCHI, M.I.; GODIÑO, M. Rendimiento y calidad de trigo : resultados del relevamiento 2000-2001=dos mil dos mil uno. [s.l.]: INIA, 2000. p.[23]. Mesa Nacional de Trigo, Uruguay.| Biblioteca(s): INIA La Estanzuela. |
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| Registros recuperados : 11 | |
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